Barbell Medicine
Episode 377: GLP-1 Anti-Obesity Medications Update-Efficacy, Muscle Risk, and Future
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2 Dec 2025 · 1h 26m
Muscle growthWeight management
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Episode Summary: The Cardiometabolic Revolution of Semaglutide, Tirzepatide, and BeyondThis episode provides a comprehensive, evidence-based update on GLP-1 receptor agonists (anti-obesity medications), featuring Dr. Jordan Feigenbaum, Dr. Austin Baraki, and Dr. Spencer Nadolsky. The hosts review the rapid evolution of these drugs—from short-acting injectables to potent multi-agonists like Tirzepatide (Mounjaro/Zepbound) and Retatrutide—which now achieve weight loss efficacy rivaling bariatric s