Barbell Medicine
Is Obesity a Willpower Problem? The Biology of Weight, Diets, and GLP-1s
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10 Jul 2026 · 1h 42m
Nutrition basicsWeight management
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About this episode
Obesity roughly tripled in about 60 years, and the genes didn't change in that time. So if body weight isn't a willpower problem, what is it? Dr. Jordan Feigenbaum and Dr. Austin Baraki walk through what actually sets your weight: the adoption and twin studies behind the genetics, the "defended range" your biology fights to hold, the food environment that does most of the eating for you, and where GLP-1 medications actually work. Along the way — why diets regain after you white-knuckle them, wha