#460: Dr. Priya Sumithran – Body Fat Regulation, Pros & Cons of Weight Loss Interventions, and GLP-1 Receptor Agonists

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Obesity increases the risk of a range of chronic diseases and negative health outcomes. And trials where a sufficient amount of weight loss is achieved show health improvements. However, despite the "straightforward" nature of causing weight loss through a hypocaloric diet, it is clear that most people who lose weight will regain some or all of the weight. This is a result of both the physiologic control of intake and expenditure (i.e. homeostatic regulation by the body to avoid staying at a low

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