
Sigma Nutrition Radio
#582: GLP-1 Agonists: Side Effects, Management and Diet – Dr. Spencer Nadolsky
New
28 Oct 2025 · 48 min
Nutrition basicsWeight management
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About this episode
GLP-1 receptor agonists have emerged as a groundbreaking tool in obesity treatment. In this episode, Dr. Spencer Nadolsky (an obesity specialist) explains how these medications are now yielding unprecedented weight loss outcomes in people with obesity. The discussion centers on GLP-1 agonist drugs like semaglutide and tirzepatide: how they work, how much weight loss they can produce, and why they represent a paradigm shift in obesity management. Importantly, the conversation addresses practical