Sigma Nutrition Radio
#594: Can Muscle Still Adapt Positively When Training Under Low Energy Availability? – Jose Areta, PhD
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10 Feb 2026 · 49 min
Muscle growth
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About this episode
Dr. José Areta and colleagues recently carried out a human intervention study examining how a pronounced, short-term energy deficit interacts with an aerobic training stimulus to shape endocrine, metabolic, and skeletal muscle proteomic adaptations. The core premise is that "low energy availability" is often discussed in a largely unidirectional risk framework, yet human physiology evolved under intermittent energy scarcity, and therefore adaptive responses may be more nuanced than "energy defic