Sigma Nutrition Radio
#596: Why Do Omega-3 Trials Show Mixed Results?
New
3 Mar 2026 · 1h 6m
Nutrition basics
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About this episode
Omega-3 fatty acids (particularly EPA and DHA) have a long history in nutrition and cardiovascular medicine, yet the clinical trial literature is often perceived as inconsistent. This episode examines why some randomized trials show clear benefit while others show null or mixed findings, and how differences in trial design, dose, population risk, and outcome selection can materially change what we observe. A key theme is separating (1) the persistent cultural narratives around omega-3s (includin